Creatine metabolism

Creatine and creatinine metabolism.

The goal of this review is to present a comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inherent implications for physiology and human pathology. Very recently, a series of new discoveries ...

Creatine metabolism and the gonads.

Creatine Kinase Activity and Cartilage Energy Metabolism: Creatine Kinase-creatine Phosphate Circuit Activity and Macromolecule Synthesis

Earlier studies showed that there is significant creatine kinase activity in the epiphyseal growth cartilage, and there is stage-specific isoform expression. To further explore the role of this enzyme in cartilage development, we disrupted the creatine kinase creatine phosphate (CK-CP) circuit using the creatine analogue, cyclocreatine. We found that while cyclocreatine decreased creatine kinas...

Effect of antidiuresis on renal creatine metabolism.

The current work investigates whether creatine metabolism is involved in renal adaptation to dehydration. Wistar rats were either deprived of water or induced to drink water abundantly during 60 h. Cortical and medullar mRNA levels of Na(+)/Cl(-)/creatine transporter (CRT), l-arginine: glycine amidinotransferase (AGAT), guanidinoacetate methyltransferase (GAMT) and of the tonicity sensitive gen...

Disorders of creatine transport and metabolism.

Creatine is a nitrogen containing compound that serves as an energy shuttle between the mitochondrial sites of ATP production and the cytosol where ATP is utilized. There are two known disorders of creatine synthesis (both transmitted as autosomal recessive traits: arginine: glycine amidinotransferase (AGAT) deficiency; OMIM 602360; and guanidinoacetate methyltransferase (GAMT) deficiency (OMIM...